Scientist in Bioanalysis
Revolution Medicines is a clinical-stage precision oncology company focused on developing novel targeted therapies to inhibit high-value frontier targets in RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) Inhibitors designed to suppress diverse oncogenic variants of RAS proteins, and RAS Companion Inhibitors for use in combination treatment strategies. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.
The Opportunity:
We are looking for an experienced Associate Scientist/Scientist to help the Discovery Sciences team accelerate our search for new oncology therapeutics. The successful candidate will join a high-performing team of experts in the use of biochemical and biophysical techniques to drive the efficient identification and rapid development of clinically impactful drugs against frontier targets in oncology. The candidate will contribute to our research portfolio from the bench by taking responsibility for developing, validating, and executing critical enabling biochemical and biophysical assays. In addition to generating high-quality experimental data, the candidate will be tasked with the analysis, curation, and dissemination of resulting insights to our research project teams to facilitate the rapid progression of our research initiatives. The successful candidate will possess the following skills, experience, and attributes:
Required Experience, Skills, and Education:
- Proficient in the design, development, and execution of microplate-based in vitro biochemical and biophysical assays suitable for the discovery, validation, and mechanistic characterization of fragment and small molecule modulators of oncology protein targets.
- Conversant in the selection and deployment of appropriate assay readouts like fluorescence polarization, TR-FRET, AlphaScreen, fluorescence, absorbance, and luminescence.
- Familiarity with surface biosensor systems to characterize compound binding and kinetics (SPR and BLI) would be a significant plus.
- Experience with delivering robust data in a timely fashion to research discovery teams is critical.
· For an associate scientist, Master’s degree in biochemistry, biophysics, chemical biology, enzymology or related field, with 5+ years of small molecule drug discovery experience with a strong track record of scientific rigor and innovation.
· For scientists, Ph.D. in biochemistry, biophysics, chemical biology, enzymology, or related field, with a strong track record of scientific rigor and innovation.
· Facile with instrumentation, able to troubleshoot problems and work with engineers to resolve issues.
· Rigorous, quantitative, detail-oriented experimentalist with an understanding of statistics.
· Excellent written and verbal communication skills.
- Innovative, team player with high energy, demonstrated a willingness to learn in a fast-paced environment.
Preferred Qualifications:
- Familiarity with protein mass spectrometry would be highly beneficial in this role.
- Familiarity with data processing and visualization tools to analyze large datasets (e.g. Genedata Screener, KNIME, or Vortex).
Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.